MADRES Sermorelin Protocol

Restore Protocol — Growth Hormone Support

Reclaim your body's natural vitality

Sermorelin gently reactivates your pituitary's own growth hormone release — restoring the energy, metabolism, and skin quality that time quietly takes away.

$247 / monthly protocol
Pharmacy503A Certified
ApprovalNo Waitlist
ShippingAlways Free
Lean Muscle PreservationMetabolic Fat ReleaseDeeper Sleep Skin & Collagen RenewalMental ClarityBone DensityLibido & Vitality Lean Muscle PreservationMetabolic Fat ReleaseDeeper Sleep Skin & Collagen RenewalMental ClarityBone DensityLibido & Vitality

Why MADRES

Healthcare finally designed around her biology — and her life.

MADRES exists because women have spent too long receiving care designed for someone else. Our physicians understand your hormones, your history, and your life — not just your symptom list.

Sermorelin is one of the most effective ways to restore the vitality that Growth Hormone decline quietly steals — without synthetic hormones, without waitlists, without compromise.

Philosophy

Unhurried. Evidence-based. Yours. We treat the whole woman, not the symptom list.

Our Physicians

Board-certified women's health specialists, licensed in your state, who review every intake personally.

Your Protocol

Compounded pharmacy. Discreet delivery. Adjusted as you evolve — not set-and-forgotten.

Ongoing Care

Unlimited messaging with your care team. Monthly check-ins. Your protocol refines with you.

The Science

Growth Hormone is your body's master regulator

Growth Hormone (GH) orchestrates muscle synthesis, fat metabolism, sleep quality, skin renewal, and cognitive function. It is not a performance drug — it is the signal that keeps your body working as it was designed to.

Sermorelin is a growth hormone-releasing peptide. Rather than introducing synthetic hormones, it signals your pituitary to resume its own natural GH production. This preserves your body's feedback loops while restoring function.

Originally FDA-approved in 1997 under the name Geref, it is now available as compounded Sermorelin Acetate through licensed 503A pharmacies — prescribed by independent licensed physicians.

12–15%
GH decline per decade after age 30
3 mo
Recommended cycle for full body composition benefit
1997
Original FDA approval — discontinued for commercial, not safety, reasons
503A
LegitScript-certified pharmacy — the highest compounding standard

Eight Ways Sermorelin Works For You

Whole-body restoration, from the inside out

01

Lean Muscle Preservation

Stimulates protein synthesis and muscle cell growth — critical for protecting body composition as metabolism shifts after 30.

02

Metabolic Fat Release

GH mobilizes stored fat for energy — especially visceral and stubborn pockets. Pairs powerfully with GLP-1 protocols.

03

Deeper Sleep & Recovery

GH is primarily released during deep sleep. Restoring it means waking truly restored — and recovering from workouts faster.

04

Skin & Collagen Renewal

Increases collagen production and accelerates skin cell turnover — visibly firmer, more luminous skin over 8–12 weeks.

05

Sustained Energy & Focus

GH enhances mitochondrial efficiency and ATP production — the biological basis for consistent, non-jittery energy all day.

06

Cognitive Sharpness

Stimulates BDNF production — the protein responsible for neuroplasticity, memory consolidation, and mental clarity.

07

Bone Density Support

GH drives bone remodeling and calcium retention — meaningful protection as estrogen naturally declines with age.

08

Libido & Vitality

GH supports luteinizing hormone, blood flow, and dopamine balance — key drivers of desire and confidence in women.

The Process

Simple. Private. Yours.

A thoughtful intake. A physician who listens. Your protocol, delivered — and a team that stays with you after.

Begin Your Consultation
01

Online · Private · Secure

Complete your health history

A thoughtful intake designed to actually understand you. Takes 5 minutes — not a generic form. Your information is HIPAA-protected and reviewed only by your assigned physician.

02

Video or Async · 48hr Turnaround

Meet your MADRES physician

A board-certified doctor, licensed in your state, reviews your history and consults with you directly. You are not charged unless approved for treatment.

03

Pharmacy Compounded · Discreet Delivery

Receive your protocol

Your personalized treatment is compounded at a 503A certified pharmacy, packaged discreetly, and delivered to your door via overnight courier — free of charge.

04

Unlimited Messaging · Monthly Check-ins

Ongoing care, not a one-time script

Your MADRES team checks in regularly. Adjust, refine, and evolve your protocol as you do. This is a relationship — not a transaction.

Your Restoration Timeline

What to expect — and when

Weeks 1–4

The Reset

Deeper, more restorative sleep. Faster recovery between workouts. Many women notice improved mood stability and reduced morning fatigue within the first two weeks.

Weeks 4–8

The Shift

Visible improvements in skin firmness and tone. Measurable strength gains. Reduced joint inflammation. Clearer mental focus and sharper cognitive recall throughout the day.

Weeks 9–12+

The Align

Full body composition improvements — fat loss and lean muscle working together. Most women describe this as feeling like themselves again, only more so.

From the MADRES Community

Women who chose to restore

"By week six my skin on my face and neck looked firmer. My trainer asked what I'd changed. I hadn't changed anything — I'd just started sleeping properly again."

Rachel M.

Age 41 · On protocol 4 months

"I was skeptical. I'm not anymore. My GLP-1 was working but I was losing muscle. Sermorelin fixed that — I'm leaner and actually stronger. The combination changed everything."

Christina V.

Age 35 · Combined with GLP-1

"I feel like my body is finally working with me. Soreness is down. Strength is up. I wake up ready. After 40 I didn't think this was possible without something drastic."

Diana K.

Age 44 · On protocol 3 months

Transparent Pricing

One protocol. Everything included.

MADRES

Sermorelin Protocol

30-day supply · Cancel or pause anytime

$247

Per month · No hidden fees, ever

Two 3mg/3ml compounded Sermorelin vials (1mg/ml)
Syringes, alcohol prep wipes, and full administration instructions
Telehealth consultation and physician prescription included
Unlimited messaging with your MADRES care team
Overnight FedEx or UPS shipping — always free
FSA / HSA eligible · No insurance required
Pre-Qualify in 60 Seconds — Save $25

Ships to: AZ, CA, CO, FL, GA, IL, IN, MA, MD, MI, MO, NC, ND, NV, NY, OH, OK, OR, PA, SC, SD, TN, TX, UT, VA, WA, WY. Cannot ship to PO boxes. You will not be charged unless approved by a licensed physician.

Safety & Medical Context

Informed decisions, supported by physicians

Why Sermorelin differs from synthetic HGH

Sermorelin stimulates your pituitary to increase its own natural GH output — it does not introduce synthetic hormones. This preserves your body's natural feedback loops, reduces the risk of receptor saturation, and means your GH levels return to pre-treatment baseline if you discontinue. It will not suppress your own natural production.

Who should not use Sermorelin

Not appropriate for individuals who are pregnant or breastfeeding, have a known allergy to Sermorelin Acetate, or have an active cancer diagnosis. Those with a history of cancer or untreated hypothyroidism should consult their physician before beginning.

Common side effects

Sermorelin is generally well-tolerated. Some individuals experience:

  • Mild injection site redness or swelling
  • Temporary headache or dizziness as the body adjusts
  • Brief flushing or warmth post-injection, most common in weeks 1–3
  • Rarely: nausea, fatigue, or mild fluid retention
Most effects are temporary. If symptoms persist or worsen, contact your care team.

Regulatory context

Sermorelin was FDA-approved in 1997 under brand name Geref, discontinued for commercial — not safety — reasons. MADRES partners exclusively with 503A LegitScript-certified pharmacies. A prescription from a licensed independent physician is required and included with every protocol.

Common Questions

Answered by our clinical team

Will I be charged before physician approval?
No. You complete checkout to hold your protocol, but your card is not charged until a MADRES-affiliated licensed physician reviews and approves your intake form. If not approved, you will not be charged and will be notified of the reason.
Can I combine this with a GLP-1 medication?
Yes — and it's one of our most recommended combinations. Sermorelin protects and builds lean muscle while GLP-1 drives weight loss. It also supports skin collagen and firmness, offsetting skin changes associated with rapid weight reduction.
How do I self-administer the injection?
Your kit includes complete illustrated instructions. The standard protocol is 250mcg/day, 5 days per week, via subcutaneous injection. Your MADRES care team is available by message to walk you through your first dose.
Can I cancel or pause my subscription?
Yes, with no penalty, anytime. We recommend completing at least 3 months to experience the full body composition benefits, but there are no lock-in requirements. Discontinuing Sermorelin will not lower your GH below your pre-treatment baseline.
How soon does my order ship after approval?
Allow up to 6 business days for physician review and pharmacy processing. Once approved, your order ships overnight via FedEx or UPS with tracking sent to your email and phone. We cannot ship to PO boxes.
Is this FSA or HSA eligible?
Yes. You may use your FSA or HSA card at checkout. MADRES does not accept insurance of any type, and there are never additional fees beyond the monthly protocol price.

Begin Your Protocol

Your body already knows how to restore itself.

Sermorelin doesn't override your biology — it returns the signal. Pre-qualify in 60 seconds and save $25 on your first month.

Pre-Qualify Now

© 2026 MADRES Health LLC. All prescription protocols require review by an independent licensed provider. Compounded medications are not FDA-reviewed for safety or efficacy. Statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a healthcare provider before making medical decisions.

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