Weight Loss Protocol — GLP-1 + GIP Dual Action
The weight loss protocol built for her biology
Tirzepatide is the only dual GLP-1 and GIP receptor agonist available. It regulates hunger signals, stabilizes blood sugar, and shifts your metabolism — not just your appetite. This is weight loss that works with your hormones, not against them.
Why Tirzepatide
Weight loss that finally makes biological sense
Most weight loss programs treat hunger as a willpower problem. It isn't. Hunger, satiety, blood sugar, and fat storage are hormonal — and in women, they are deeply intertwined with estrogen, cortisol, and insulin. Tirzepatide works at the receptor level to reset these signals.
As a dual GLP-1 and GIP agonist, Tirzepatide activates two distinct metabolic pathways simultaneously — reducing appetite, improving insulin sensitivity, slowing gastric emptying, and driving fat oxidation. Clinical trials showed over 20% body weight reduction at maximum dosing over 72 weeks.
Philosophy
Unhurried. Evidence-based. Yours. We treat the whole woman — your weight, your hormones, your history.
Our Physicians
Board-certified women's health specialists who personalize your dosing plan and check in throughout your journey.
Your Protocol
Compounded Tirzepatide from 503A-certified pharmacies. Discreet delivery. Gradual dose escalation for your comfort.
Ongoing Support
Unlimited messaging with your care team. Regular check-ins. No set-it-and-forget-it prescriptions here.
The Science
Two receptors. One protocol. Outcomes no single-agonist can match.
GLP-1 receptor agonists reduce appetite and slow gastric emptying. GIP receptor agonists improve insulin sensitivity and enhance fat metabolism. Tirzepatide activates both simultaneously — producing synergistic effects that clinical studies show are measurably superior to GLP-1 alone.
In the SURMOUNT-1 trial, participants lost an average of 21% of body weight at the highest dose over 72 weeks. For women, the metabolic impact extends beyond weight — improving blood sugar regulation, reducing inflammation, and supporting the hormonal environment that makes sustainable change possible.
Compounded Tirzepatide is not the same as brand-name Zepbound® or Mounjaro®. MADRES provides compounded Tirzepatide through licensed 503A pharmacies and is not affiliated with Eli Lilly.
How Tirzepatide Works For You
Six mechanisms. One integrated result.
01
Appetite & Craving Control
Activates GLP-1 receptors in the brain that regulate hunger signals and reward-driven eating — reducing cravings and the mental preoccupation with food that diets alone cannot fix.
02
Blood Sugar Stabilization
Stimulates glucose-dependent insulin release and suppresses glucagon — keeping blood sugar steady and reducing the spikes and crashes that drive energy loss and fat storage in women.
03
Enhanced Fat Metabolism
GIP receptor activation improves the way your body stores and mobilizes fat — particularly the visceral and hormonal fat that becomes stubborn after 35 as estrogen shifts.
04
Sustained Satiety
Slows gastric emptying so meals stay with you longer — reducing total caloric intake naturally, without the deprivation that makes other protocols unsustainable long-term.
05
Insulin Sensitivity
Reduces insulin resistance — a key driver of weight gain in women over 35 and a critical factor in metabolic health, PCOS, perimenopause, and long-term disease prevention.
06
Inflammation Reduction
As metabolic function improves, systemic inflammation decreases — contributing to better joint health, skin clarity, mood stability, and the overall sense of vitality that weight alone doesn't explain.
Your Dosing Journey
A gradual escalation designed for your comfort
Tirzepatide is introduced slowly to allow your body to adjust at each level. Your MADRES physician personalizes your plan — the timeline below reflects the standard approach.
Phase One
The Introduction
2.5mg → 5mg → 7.5mg weekly
Weeks 1 through 12. Dose is increased every 4 weeks as tolerated. Most women notice reduced appetite and steadier energy within the first two weeks. Side effects, if any, are typically mild and dose-dependent.
Phase Two
The Optimization
7.5mg → 10mg → 15mg weekly
Weeks 12 and beyond. Your physician guides escalation based on your response, weight trajectory, and tolerance. Many women find their optimal dose before reaching 15mg. This is where body composition changes become most visible.
Choose Your Protocol
Transparent pricing. No surprises.
All plans include physician consultation, prescription, and free overnight shipping. You are not charged unless approved.
Phase One Kit
Low-dose introduction · Weeks 1–4
$296
Per month · No hidden fees
Standard Protocol
Mid-range dosing · Weeks 4–12
$346
Per month · No hidden fees
Optimization Protocol
High-dose · Weeks 12+
$396
Per month · No hidden fees
FSA / HSA eligible. Ships to: AZ, CA, CO, FL, GA, IL, IN, MA, MD, MI, MO, NC, ND, NV, NY, OH, OK, OR, PA, SC, SD, TN, TX, UT, VA, WA, WY. No PO boxes.
The Process
Simple. Private. Yours.
A thoughtful intake. A physician who personalizes your dose. Your protocol delivered — and a team that adjusts with you every step.
Pre-Qualify in 90 SecondsOnline · Private · Secure
Complete your health history
A thoughtful intake that covers your weight history, metabolic health, medications, and goals. Takes 5 minutes. HIPAA-protected and reviewed only by your assigned physician.
Physician Review · 48hr Turnaround
Receive your personalized dosing plan
A board-certified doctor reviews your intake and creates a custom escalation plan. You are not charged unless approved. Your physician remains available throughout your protocol.
Pharmacy Compounded · Discreet Delivery
Your kit arrives at your door
Compounded at a 503A LegitScript-certified pharmacy and shipped overnight via FedEx or UPS. Everything you need is included — vials, syringes, wipes, and a welcome guide for your first injection.
Ongoing · Adjustable · Yours
Your team evolves your protocol with you
Regular check-ins to assess your response, adjust your dose, and pair complementary protocols like Sermorelin for muscle preservation. No set-it-and-forget-it. No auto-ship you can't control.
From the MADRES Community
Women who chose to restore
"I lost 34 pounds in five months and kept every bit of muscle. Adding Sermorelin to my Tirzepatide protocol was the best decision I made. My skin didn't sag. I didn't lose my strength. I just lost the weight."
Carla M.
Age 43 · Combined protocol · 5 months
"The cravings just stopped. Not suppressed — gone. For the first time I wasn't fighting myself at 9pm. The weight came off because my whole relationship with food changed."
Vanessa R.
Age 38 · Tirzepatide · 4 months
"I'd tried everything. This was different because my doctor actually adjusted my dose as I went. I didn't plateau. I didn't feel abandoned after the first prescription. MADRES stayed with me."
Sofia L.
Age 51 · On protocol 7 months
Safety & Medical Context
Informed decisions, supported by physicians
How Tirzepatide works in the body
Tirzepatide is a dual GLP-1 and GIP receptor agonist administered as a once-weekly subcutaneous injection. It regulates appetite signals in the brain, slows gastric emptying, stimulates insulin release in a glucose-dependent manner, and suppresses glucagon — working through two complementary pathways to produce metabolic effects that single-agonist medications cannot replicate.
Who should not use Tirzepatide
Not appropriate for individuals who are pregnant or breastfeeding, have a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, have a history of pancreatitis, or have type 1 diabetes. Caution is advised for those with severe gastrointestinal conditions, kidney disease, or a history of gallbladder disease. Your physician reviews all contraindications at intake.
Common side effects
Most side effects are gastrointestinal, dose-dependent, and improve as your body adjusts:
- Nausea — most common in early weeks, especially after dose increases
- Reduced appetite and changes in food preferences
- Mild diarrhea or constipation
- Fatigue during the initial adjustment period
- Injection site redness or mild irritation
Regulatory & pharmacy context
Compounded Tirzepatide is not the same as brand-name Zepbound® or Mounjaro®, and makes no claim of equivalent results to clinical trials conducted with those medications. MADRES is not affiliated with Eli Lilly. Compounded medications are not FDA-reviewed for safety or efficacy but are prepared under strict FDA regulations by state-licensed 503A LegitScript-certified pharmacies. A prescription from a licensed independent physician is required and included with every protocol.
Common Questions
Answered by our clinical team
Begin Your Protocol
Your weight is a hormone story. Let's rewrite it.
Tirzepatide works with your biology — not against it. Pre-qualify in 90 seconds and take the first step toward a protocol designed for how your body actually works.
Pre-Qualify NowCompounded Tirzepatide is not FDA-approved and is not the same as brand-name Zepbound® or Mounjaro®. MADRES is not affiliated with Eli Lilly Company. Compounded medications may contain FDA-approved ingredients but are not themselves FDA-approved. Clinical trial results referenced are based on studies using brand-name tirzepatide; compounded tirzepatide makes no claim of equivalent results. All prescription protocols require review and approval by an independent licensed physician. Always consult your primary care provider before beginning any new medication.
© 2026 MADRES Health LLC. All prescription protocols require review by an independent licensed provider. Compounded medications are not FDA-reviewed for safety or efficacy. Statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a healthcare provider before making medical decisions.